Unusual terpenylated acylphloroglucinols from Dryopteris wallichiana

CECILIA SOCOLSKY; LAURA DOMÍNGUEZ; YOSHINORI ASAKAWA; ALICIA BARDÓN

PHYTOCHEMISTRY

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2012 vol. 80 p. 115 - 122

0031-9422

Four unusual terpenylated acylphloroglucinols were isolated from the diethyl ether extract of the scales and rhizomes of the fern Dryopteris wallichiana together with the known compounds albaspidins AA and AB, and filixic acids ABA and ABB. Structures of the isolated compounds were established by extensive spectroscopic analysis and their absolute configurations at C-14´´ was determined by comparing their CD spectra with those simulated for the respective isomers. Pure acylphloroglucinols displayed moderate in vitro nematocidal activity agains L4 stage larvae of Nippostrongylus brasiliensis (LD50 = 22-121 microM).