INQUINOA   21218
INSTITUTO DE QUIMICA DEL NOROESTE
Unidad Ejecutora - UE
artículos
Título:
Effect of different C3-aryl substituents on the antioxidant activity of 4-hydroxycoumarin derivatives.
Autor/es:
RODRÍGUEZ, S. A.; NAZARENO, M. A.; BAUMGARTNER, M. T.
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdan; Año: 2011 vol. 19 p. 6233 - 6238
ISSN:
0968-0896
Resumen:
The antioxidant activity of 4-hydroxycoumarin synthetic derivatives and 4-methylumbelliferone were determined taking 4-hydroxycoumarin as the reference compound. Six 3-aryl-4-hydroxycoumarin derivatives were synthesized from 4-hydroxycoumarin as precursor in order to evaluate changes in their antioxidant properties due to C3-aryl substituent nature. Free radical scavenging capacities of these compounds against two different species DPPH and ABTS and the protecting ability towards the b-carotene-linoleic acid co-oxidation enzymatically induced by lipoxygenase were measured. In addition, the relationship between the activities of these molecules against DPPH radical and the bond dissociation energy of O–H (BDE) calculated using methods of computational chemistry was evaluated.