INQUINOA 21218
INSTITUTO DE QUIMICA DEL NOROESTE
Unidad Ejecutora - UE
artículos
Título:
CHEMICAL CONSTITUENTS, ANTI-INFLAMMATORY, AND ANTIOXIDANT ACTIVITIES OF BARK EXTRACTS FROM PRUNUS TUCUMANENSIS
Autor/es:
SANDRA M. BACH, MARINA E. PEROTTI, ANA P. MEREP, GUILLERMO E. MARCIAL, ALFREDO GRAU, RODGOUN ATTARIAN, HORACIO BACH, YOSSEF AV-GAY, AND CÉSAR A. N. CATALÁN
Revista:
NATURAL PRODUCT RESEARCH
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Lugar: Londres; Año: 2012
ISSN:
1478-6419
Resumen:
The anti-inflammatory, antioxidant, antimicrobial, and cytotoxic activities of the hexane (HE), chloroform (CE) and methanol (ME) extracts obtained from the bark of Prunus tucumanensis Lillo were investigated. Both ME and CE extracts displayed a significant in vitro anti-inflammatory activity similar to dexamethasone and to a commercial formulation (Pygeum) used for the treatment of benign prostatic hyperplasia (BPH). ME exhibited powerful antioxidant (67.6% relative to BHT) and free radical scavenging (RC50=5 ppm) activities, antimicrobial activities against Staphylococcus aureus and Mycobacterium smegmatis, and did not show any cytotoxic effect on human-derived macrophage cells. Chemical analyses showed that (2R,3R)-3,5,7,3¡¦,5¡¦-pentahydroxyflavan, Ò-sitosterol and Ò-sitosterol-3-O-Ò-D-glucopyranoside (daucosterol) are relevant components of ME.
