INVESTIGADORES
ZARATE Sandra Cristina
capítulos de libros
Título:
The role of estrogens in anterior pituitary gland remodeling during the estrous cycle
Autor/es:
ZÁRATE SANDRA; ZALDIVAR VERÓNICA; JAITA GABRIELA; MAGRI LAURA; RADL DANIELA; PISERA DANIEL; SEILICOVICH ADRIANA
Libro:
Pituitary Today II New Molecular, Physiological and Clinical Aspects
Editorial:
KARGER
Referencias:
Año: 2010; p. 25 - 31
Resumen:
In the present review we analyze the actions of estrogens leading to the remodeling of the anterior pituitary gland, especially during the estrous cycle. Proliferation and death of anterior pituitary cells and especially lactotropes is regulated by estrogens, which act sensitizing these cells to both mitotic and apoptotic stimuli such as TNF-á, FasL and dopamine. During the estrous cycle, the changing pattern of gonadal steroids is thought to modulate both cell proliferation and death in the anterior pituitary gland, estrogens being key players in cell turnover. The mechanisms involved in estrogen-modulated cell renewal in the anterior pituitary gland during the estrous cycle might include the increase in the expression of proapoptotic cytokines as well as the increase in the Bax/Bcl-2 ratio at proestrus, when estrogen levels are the highest and a peak of apoptosis, in particular of lactotropes, is evident in this gland. Estrogens exert rapid antimitogenic and proapoptotic actions in the anterior pituitary through membrane-associated estrogen receptors, a mechanism that might also be involved in remodeling of this gland during the estrous cycle.