INVESTIGADORES
RUMBO Martin
artículos
Título:
Effect of the semisynthetic form of glucagon-like peptide-2 analog in an experimental model of intestinal ischemia-reperfusion injury
Autor/es:
MOREIRA, JEREMIAS E.; STRINGA, PABLO; GENTILINI, MARÍA VIRGINIA; ARRIOLA, CONSTANZA; IVANOFF, IVANA; RUMBO, MARTÍN; GONDOLESI, GABRIEL E.
Revista:
JOURNAL OF GASTROINTESTINAL SURGERY : OFFICIAL JOURNAL OF THE SOCIETY FOR SURGERY OF THE ALIMENTARY TRACT.
Editorial:
SPRINGER
Referencias:
Año: 2024 vol. 28 p. 1169 - 1171
ISSN:
1091-255X
Resumen:
Intestinal ischemia-reperfusion injury (IRI) is inherent to the transplant procedureand responsible for direct (early mucosal damage) and indirect injuries (lungdisease). The loss of the mucosal barrier function and the structure of intestinal villi,would release pro-inflammatory cytokines, causing tissue damage in remote organs 1 .Glucagon-like peptide-2 (GLP-2) is a hormone secreted by enteroendocrine L cellsof the intestinal epithelium that has a trophic effect on intestinal epithelium 2 . Althoughtherapeutic use of the semisynthetic form of GLP-2 (sGLP-2) in intestinalrehabilitation has been established 3 , few experimental studies have shown apotential use to reduce IRI. Our aim was to evaluate a possible protective effect ofsGLP-2 in reducing local and remote organ IRI damage in a mouse model, aspreliminary analysis to be then applied in further transplant models or in the clinicalsetting.
