INVESTIGADORES
PASQUEVICH Gustavo Alberto
artículos
Título:
A SIMPLE AND EFFICIENT PROCEDURE FOR THE SYNTHESIS OF FERROGELS BASED ON PHYSICALLY CROSSLINKED PVA
Autor/es:
JIMENA SOLEDAD GONZALEZ; CRISTINA ELENA HOPPE; PEDRO MENDOZA ZÉLIS; LORENA ARCINIEGAS; GUSTAVO PASQUEVICH; FRANCISCO H SANCHEZ; VERA ALEJANDRA ALVAREZ
Revista:
INDUSTRIAL & ENGINEERING CHEMICAL RESEARCH
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2014 vol. 53 p. 214 - 221
ISSN:
0888-5885
Resumen:
Ferrogels with well dispersed single-domain magnetic NPs were obtained by infusion of iron salts in physically crosslinked PVA hydrogels followed by coprecipitation. Freezing thawing (F-T) was used as a cryogenic technique to form mechanically strong and highly swellable hydrogels. Networked structure of the final material was used as a constrained environment useful for the precipitation of iron oxide NPs and formation of the magnetic gel. A homogeneous, single domain ensemble of more than 15 wt% of iron oxide NPs (in only one cycle of absorption) could be obtained through this easy technique. Moreover, capacity of these magnetic ferrogels to absorb high amounts of ethanol/water solutions allows impregnation of these materials with ibuprofen and subsequent release of the drug at physiological pH. Biocompatibility of the components and the use of a non-toxic PVA crosslinking strategy (F-T) make these materials promising for drug delivery applications.