Delayed and bilateral changes of GAP-43/B-50 phosphorylation after circling training during a critical period in rat striatum

AZCURRA JM; SOIZA-REILLY M; FOSSATI M; PARATCHA GCH

MOLECULAR BRAIN RESEARCH

Elsevier

Lugar: Amsterdam; Año: 2003 vol. 118 p. 166 - 170

0169-328X

During the critical period of activity-dependent plasticity in rat striatum (30-37 days after birth) physiological circling behavior induces delayed modifications in GAP-43/B-50 phosphorylation by PKC. Postexercise, ipsi- and contralateral striatum to the circling direction show a similar temporal pattern of GAP-43/B-50 phosphorylation, with an initial decrease followed by a subsequent increase. However, there is a lag between initiation of the phosphorylation response in this asymmetrical task which does not occur when animals are subjected to exercise under conditions of symmetrical motor activity.