RET receptor integrates tumor cell-adipocyte communication to promote breast cancer.

SABRINA VALLONE; IRENE RUIZ ; ANGELA LARA; IVANA NIKOLIC; ALBA C. ARCONES; MARCOS PALAVECINO; MARTÍN GARCÍA SOLÁ; GLADYS N. HERMIDA; JULIAN NAIPAUER; GUADALUPE SABIO; ALBANA GATTELLI

Simposio; RET receptor integrates tumor cell-adipocyte communication to promote breast cancer.; 2024

Adipocytes are the specialized cells for lipids storage and form the major cellularcomponent of the breast organ microenvironment. The adipose tissue next to thebreast tumor consists of modified adipocytes that share similarities with theirprecursors, known as pre-adipocytes. Understanding the interaction between both celltypes will guide novel therapeutic strategies to treat breast tumors. Here, we identifyRET receptor tyrosine kinase as a regulator of breast tumor-adipose tissue interplay.