INVESTIGADORES
GIULIANELLI Sebastian Jesus
artículos
Título:
Progesterone receptors in normal breast development and breast cancer
Autor/es:
GIULIANELLI, SEBASTIAN; LAMB, CAROLINE A.; LANARI, CLAUDIA
Revista:
ESSAYS IN BIOCHEMISTRY
Editorial:
PORTLAND PRESS LTD
Referencias:
Año: 2021 vol. 65 p. 951 - 969
ISSN:
0071-1365
Resumen:
Progesterone receptors (PR) play a pivotal role in many female reproductive tissues such as the uterus, the ovary, and the mammary gland (MG). Moreover, PR play a key role in breast cancer growth and progression. This has led to the development and study of different progestins and antiprogestins, many of which are currently being tested in clinical trials for cancer treatment. Recent reviews have addressed the role of PR in MG development, carcinogenesis, and breast cancer growth. Thus, in this review, in addition to making an overview on PR action in normal and tumor breast, the focus has been put on highlighting the still unresolved topics on hormone treatment involving PR isoforms and breast cancer prognosis.