INVESTIGADORES
SABINI Maria Carola
artículos
Título:
Protective role of chlorogenic acid on DNA damage caused by ochratoxin A exposure
Autor/es:
CAMPRA NOELIA; CARIDDI LAURA NOELIA; ESCOBAR FRANCO MATÍAS; SABINI MARÍA CAROLA; FREIRE DE LIMA CELIO; DECOTE RICARDO DEBORA; ROMA DARDO; MAÑAS FERNANDO; DALCERO ANA MARIA
Revista:
ANALECTA VETERINARIA
Editorial:
FACULTAD DE CIENCIAS VETERINARIAS, UNIVERSIDAD NACIONAL DE LA PLATA
Referencias:
Lugar: La Plata; Año: 2020
Resumen:
Chlorogenic acid (ChlA) has shown short-term protective effects against the cytogenotoxiceffects of ochratoxin A (OTA). e present study evaluated the effect of oraladministration of ChlA in male Wistar rats exposed to OTA. OTA (0.4 mg/kg bw/day), ChlA (5 mg/kg bw/day), or the combination of both, were administered orally toanimals during 28 days. No deaths, decrease in feed consumption or change in the bodyweight of animals were observed in any group. In the OTA-treated group a decrease inlocomotion as well as increased DNA damage in blood, kidney and bone marrow cellswere observed. ChlA alone was not genotoxic for animals. e combination of OTA+ChlA decreased the DNA damage by 37% in blood cells, by 55% in kidney cells andby 80% in bone marrow cells compared to OTA-treated group. In conclusion, oraltreatment with ChlA showed a good protective effect on genotoxicity produced byOTA in rats during 28 days exposure.