INVESTIGADORES
SABINI Maria Carola
artículos
Título:
Phenolic acid protects of renal damage induced by ochratoxin A in a 28-days-oral treatment in rats.
Autor/es:
CARIDDI LAURA NOELIA; ESCOBAR FRANCO MATÍAS; SABINI MARÍA CAROLA; CAMPRA NOELIA; BAGNIS GUILLERMO; DECOTE-RICARDO D; FREIRE-DE-LIMA CG; MAÑAS FERNANDO; SABINI LILIANA INÉS; DALCERO ANA MARIA
Revista:
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2016 vol. 43 p. 105 - 111
ISSN:
1382-6689
Resumen:
The present study aimed to characterize the chlorogenic acid (ChlA) capacity to reverse the toxic effectsinduced by ochratoxin A (OTA) in a subacute toxicity test in rats. Male Wistar rats were fed orally by gav-age for 28 days with OTA (0.4 mg/kg bw/day), ChlA (5 mg/kg bw/day) or the combination OTA (0.4 mg/kgbw/day) + ChlA (5 mg/kg bw/day). No deaths, no decrease in feed intake or body weight in any experimen-tal group were recorded. The negative control group and the animals treated with ChlA alone showed nochanges in any parameters evaluated. In OTA-treated group significant changes such as decrease in urinevolume, proteinuria, occult blood, increase in serum creatinine values; decrease in absolute and relativekidney weight and characteristics histopathological lesions that indicated kidney damage were observed.However, limited effect on oxidative stress parameters were detected in kidneys of OTA-treated group.Animals treated with the combination OTA + ChlA were showed as negative control group in the evalua-tion of several parameters of toxicity. In conclusion, ChlA, at given concentration, improved biochemicalparameters altered in urine and serum and pathological damages in kidneys induced by OTA exposure,showing a good protective activity, but not by an apparent antioxidant mechanism.