INVESTIGADORES
SABINI Maria Carola
artículos
Título:
Polyphenols as possible bioprotectors against cytotoxicity and DNA damage induced by ochratoxin A
Autor/es:
CARIDDI LAURA NOELIA; SABINI MARÍA CAROLA; ESCOBAR FRANCO MATÍAS; MONTIRONI IVANA; MAÑAS FERNANDO; IGLESIAS DELVIS; COMINI LAURA; SABINI LILIANA INÉS; DALCERO ANA MARIA
Revista:
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 39 p. 1008 - 1018
ISSN:
1382-6689
Resumen:
The present study aimed to investigate the protective effects of luteolin (L), chlorogenic acid(ChlA) and caffeic acid (CafA) against cyto-genotoxic effects caused by OTA. Vero cells andrat lymphocytes were used and viability was measured by neutral red uptake, MTT andtrypan blue dye exclusion method. L (50 and 100 g/mL), ChlA (100 and 200 g/mL) and CafA(10?50 g/mL) reduced the damage induced by OTA (10 g/mL) on both cells type shown agood protective effect. The comet and micronucleus tests in Balb/c mice were performed.ChlA (10 mg/kg bw) reduced OTA (0.85 mg/kg bw)-induced DNA damage on blood and bonemarrow cells, CafA (10 mg/kg bw) showed protective effect only in blood cells and luteolin(2.5 mg/kg bw) failed to protect DNA integrity on cells. In conclusion, polyphenols testedreduced the toxicity caused by OTA on different target cells with good protective effect,being ChlA the compound that showed the best effects.