Direct arylation-based synthesis of carbazoles using an efficient palladium nanocatalyst under microwave irradiation

H. SEBASTIÁN STEINGRUBER; PAMELA MENDOROZ; MARÍA A. VOLPE; DARÍO C. GERBINO

Basel

Conferencia; ECSOC 24; 2020

Herein, an eco-friendly palladium-catalyzed tandem reaction for the one-pot synthesis ofcarbazoles under microwave irradiation is reported. This approach involves an amination and adirect arylation from available and inexpensive anilines and 1,2-dihaloarenes. For the developmentof this purpose, a novel recoverable palladium nanocatalyst supported on a green biochar underligand-free conditions is used. Compared with other existing palladium-based protocols, the presentsynthetic methodology shows a drastic reduction in reaction times and excellent compatibilitywith different functional groups, allowing to obtain a small library of carbazoles with high yieldsand regioselectivity. The novel heterogeneous palladium nanocatalyst can be recycled and reusedup to five times without significant loss activity.