GERBINO dario Cesar
EFFECTS OF HYDROXY-XANTHONES ON DIPALMITOYLPHOSPHATIDYLCHOLINE LIPID BILAYERS: A THEORETICAL AND EXPERIMENTAL STUDY
M. BELÉN SIERRA; LAUREANO ALARCON; DARÍO C. GERBINO; VIVIANA PEDRONI; FLAVIA BUFFO
CHEMISTRY AND PHYSICS OF LIPIDS
ELSEVIER IRELAND LTD
Lugar: Amsterdam; Año: 2017 vol. 206 p. 1 - 8
Xanthones and derivatives are natural active compounds whose interest has beenincreased due to its several pharmacological effects. In this work, effects ofhydroxy-xanthones on the physicochemical properties of dipalmitoylphosphatidylcholine (DPPC) liposomes have been investigated in termsof lipid bilayer fluidity, by means of molecular dynamics simulations andtemperature dependence of zeta potential studies. Experimental results predict, ingood agreement with simulations, that xanthones are able to be incorporated intoDPPC liposomes with certain localization, fluidizing the bilayer. Both effects,localization and fluidity were found to be dependent of the number of hydroxilicsubstituents of the xanthone and the lipid phase state.