INVESTIGADORES
GERBINO dario Cesar
artículos
Título:
A novel Palladium based heterogenous catalyst for tandem annulation: A strategy for direct synthesis of acridones
Autor/es:
H. SEBASTIÁN STEINGRUBER; PAMELA MENDOROZ; M. JULIA CASTRO; MARÍA A. VOLPE; DARÍO C. GERBINO
Revista:
SYNTHESIS-STUTTGART
Editorial:
GEORG THIEME VERLAG KG
Referencias:
Año: 2022
ISSN:
0039-7881
Resumen:
In order to develop an efficient, rapid and modular cascade strategy for the direct synthesis of acridones, palladium supported on sulfated alumina and microwave activation are employed. Multifunctional heterogeneous palladium catalysts were prepared in order to carry out the sequential annulation via a Buchwald-Hartwig amination followed by an intramolecular annulation in a one-pot process. This new protocol represents the first report on a catalytic tandem synthesis of acridone derivatives from commercially available starting materials, under ligand-free conditions. The scope of the present methodology is extended to the generation of a library of functionalized acridones, showing high functional group compatibility, in moderate to excellent yields. The applicability of this novel transformation was demonstrated by the concise total synthesis of the natural product arborinine