Serum corticosterone and Ig A levels increase in hyperthyroidism and exhibit a positive correlation

SÁNCHEZ, M. B.; MICHEL, M. C.; NEIRA, F. J.; VIRUEL, L. B.; GOMEZ S. B.; CUELLO CARRIÓN, F. D.; RODRÍGUEZ-CAMEJO, C.; TRONCOSO M.; PIETROBON, O. E.; SOAJE, M.; HERNÁNDEZ A.; JARA, E. L.; VALDÉZ, S. R.; MACKERN OBERTI, J. P.

San Luis

Congreso; XLII Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2024

Sociedad de Biología de Cuyo

Immune homeostasis is partly regulated by different physiological systems, especially the endocrine. Thyroid hormones (THs) play a key regulatory role in the immune system, influencing immune cell populations and cytokine expression. THs regulate the proliferative potential of developing B-cell precursors and also affect the proliferation and functionality of plasma cells. Hyperthyroidism (HyperT) is characterized by excessive thyroid gland activity, leading to the overproduction of THs. However, the role of HyperT in modulating immune responses and antibody production remains unclear. Our work aimed to evaluate the impact of HyperT on endocrine status and antibody production. For this purpose, twelve-week-old female Wistar rats received daily injections of 0.25 mg/kg T4 (HyperT, n=15) or vehicle (control, n=10) for 30 days, after which they were euthanized on the estrus day. Serum levels of total T4, corticosterone, prolactin and progesterone were measured using RIA and electrochemiluminescence. Total IgG, IgG2a and IgA levels were analyzed by ELISA. Our results confirmed successful induction of HyperT, as indicated by elevated total T4 levels (p