CESIMAR - CENPAT   25625
CENTRO PARA EL ESTUDIO DE SISTEMAS MARINOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
The antiviral properties of the sea urchins.
Autor/es:
BARBIERI, ELENA S.; CARDOZO, DANA; FERNÁNDEZ, JIMENA P.; GAZQUEZ, AYELÉN; GITTARDI, A; SEPÚLVEDA, LUCAS R.; RUBILAR, T.; AVARO, MARISA G.; VERA-PIOMBO, MERCEDES
Lugar:
Cambridge
Reunión:
Exposicin; Virtual Radcliffe Seminar: South-to-South Collaboration on Vaccines and Therapeutics Innovation; 2020
Institución organizadora:
Harvard University
Resumen:
The SARS-CoV-2 outbreak has spread rapidly and globally generating a new coronavirusdisease (COVID-19) since December 2019 that turned into a pandemic. Effective drugs areurgently needed and drug repurposing strategies offer a promising alternative to dramaticallyshorten the process of traditional de novo development. Methods: Based on their antiviral uses,the potential affinity of sea urchin pigments to bind the main protease (Mpro) and the Spikeglycoprotein of SARS-COV-2 was evaluated in silico. Docking analyses were used to test thepotential of these sea urchin pigments as therapeutic and antiviral agents and compared withknown drugs. In addition, a comprehensive literature and patent search review was undertakenusing PubMed, as well as Google Scholar and Espacenet engines to review on these areas.Conclusions: All pigment compounds presented high molecular affinity to these proteins.However, the polihydroxilated 1,4-naphtoquinones, Spinochrome A and Echinochrome A,showed high affinity for these proteins and were predicted to performed better than the rest ofthe pigments in terms of pharmacokinetics and complexity of synthesis. All these resultsprovide novel information regarding the uses of sea urchin pigments as antiviral drugs andsuggest the need for further in vitro and in vivo analysis to expand all therapeutic uses againstSARS-CoV-2. Polihydroxilated 1,4-naphtoquinones are candidate drug to treat Cytokine StormSyndrome (CSS) produce by SARS-CoV-2.