congresos y reuniones científicas
OSCILLATORY BRAIN ACTIVITY INDUCED BY TARGET MEMORY REACTIVATIONS DURING SLOW WAVE SLEEP: PRELIMINARY RESULTS
MOYANO MALEN; DIEKELMANN SUSANNE; BRUSCO IGNACIO; FORCATO CECILIA
Congreso; XXXIV Reunión Anual SAN 2019; 2019
consolidated memories can be reactivated by a reminder of the original memory; followed by a process of re-stabilization known as reconsolidation. Sleep is known to support the consolidation of newly encoded memories and we have recently demonstrated that sleep has a beneficial role on reconsolidation correlating the slow wave activity (0.5-8Hz) during NREM sleep with memory re-stabilization. Several studies, induced reactivations during the sleep period after acquision, by presenting cues previously associated with the learned material, showing an enhanced performance after reactivation. However, only one study in mice provides evidence that consolidated memories can also be strengthened by presenting cues during sleep and that this process is mediated by labilization/restabilization mechanisms. So, here we test if a human consolidated declarative memory can be modified during Slow Wave Sleep (SWS) by presenting auditory cues associated to the learned task. For that, participants were trained on day 1 in a sound-word paradigm. On day 2 they slept for 90 minutes and they received or not, during SWS, reminders of the learned associations. They were tested 30 min after being awaken. Preliminary results show that participants that received reminders during SWS showed a better performance than the no reactivated group. Reactivation during SWS were associated to an increase in theta and spindle power during cue presentation.