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Reconsolidation does not occur whenever a memory is retrieved: The specificity of the reminder structure.
CECILIA FORCATO; PABLO ARGIBAY; MARÍA EUGENIA PEDREIRA; HÉCTOR MALDONADO
Workshop; Neuronal Communication: From structure to psysiology.; 2008
Memory reconsolidation is defined as a process in which the retrieval of a previouslyconsolidated memory returns to a labile state which is then subject to stabilization. Thereminder is the event that begins with the presentation of the learned cue and triggersthe labilization-reconsolidation process. Since the early formulation of the hypothesis,several controversial items have arisen concerning the conditions that definereconsolidation.It is herein proposed that two diagnostic features characterize reconsolidation, namely:the labilization of the reactivated memory and the specificity of the reminder structure.To study this proposal, subjects received two different training sessions on verbalmaterial on Day 1 and Day 2, respectively. Finally, they were tested for the first andsecond acquired memories on Day 3. It is demonstrated that the human declarativememory fulfills the two requirements that define the process. First, the reactivatedmemory is impaired by a new learning only when it is given closely after the reminder,revealing that the memory is labilized. Second, the omission of at least one of thereminders components prevents labilization.Therefore, results show that the new learning fails to produce an amnesic effect on thetarget memory either when the reminder omits the learned cue or includes the beginningof the reinforcement.