Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans
FORCATO, CECILIA; KLINZING, JENS G.; CARBONE, JULIA; RADLOFF, MICHAEL; WEBER, FREDERIK D.; BORN, JAN; DIEKELMANN, SUSANNE
Año: 2020 vol. 3
Reactivation by reminder cues labilizes memories during wakefulness, requiring reconsolidation to persist. In contrast, during sleep, cued reactivation seems to directly stabilizememories. In reconsolidation, incomplete reminders are more effective in reactivatingmemories than complete reminders by inducing a mismatch, i.e. a discrepancy betweenexpected and actual events. Whether mismatch is likewise detected during sleep is unclear.Here we test whether cued reactivation during sleep is more effective for mismatch-inducingincomplete than complete reminders. We first establish that only incomplete but not complete reminders labilize memories during wakefulness. When complete or incompletereminders are presented during 40-min sleep, both reminders are equally effective in stabilizing memories. However, when extending the retention interval for another 7 hours(following 40-min sleep), only incomplete but not complete reminders stabilize memories,regardless of the extension containing wakefulness or sleep. We propose that, during sleep,only incomplete reminders initiate long-term memory stabilization via mismatch detection.