Interference conditions of the reconsolidation process in humans: the role of valence and different memory systems.
RODRIGO S. FERNÁNDEZA; LUZ BAVASSI; LAURA KACZER; CECILIA FORCATO; MARÍA EUGENIA PEDREIRA
FRONTIERS IN HUMAN NEUROSCIENCE
FRONTIERS RES FOUND
Following the presentation of a reminder, consolidated memories become reactivated followed by a process of re-stabilization,which is referred to as reconsolidation. The most common behavioral tool used to reveal this process is interference produced bynew learning shortly after memory reactivation. Memory interference is defined as a decrease in memory retrieval, the effect isgenerated when new information impairs an acquired memory. In general, the target memory and the interference task used arethe same. Here we investigated how different memory systems and/or their valence could produce memory reconsolidationinterference. We showed that a reactivated neutral declarative memory could be interfered by new learning of a differentneutral declarative memory. Then, we revealed that an aversive implicit memory could be interfered by the presentation of areminder followed by a threatening social event. Finally, we showed that the reconsolidation of a neutral declarative memory isunaffected by the acquisition of an aversive implicit memory and conversely, this memory remains intact when the neutraldeclarative memory is used as interference. These results suggest that the interference of memory reconsolidation is effectivewhen two task rely on the same memory system or both evoke negative valence.