INVESTIGADORES
CANOSA luis fabian
congresos y reuniones científicas
Título:
Regulation of somatic growth and gene expression of the GH/IGF system and muscle growth biomarkers myostatin and myogenin by dietary lipids in juveniles of the pejerrey (Odontesthes bonariensis)
Autor/es:
GÓMEZ-REQUENI P; VILLIAN M; BOERI R; CANOSA LF
Lugar:
Ciudad Autonoma de Buenos Aires
Reunión:
Simposio; 7th Intrenational Symposium on Fish Endocrinology; 2012
Resumen:
Growth and mRNA levels of growth hormone receptors
(GHRs), insulin-like growth factors (IGFs) and muscle growth biomarkers
myostatin (MSTN) and myogenin (MyoG) were analyzed in juveniles of pejerrey fed
with graded levels of dietary lipids (L) ranging 6%, 10% and 25%. At the end of
the 14-week trial, growth rates were higher with L10 and L25 paralleled by a decrease
in liver IGF-I expression. Hepatic GHR-I mRNA levels followed the same trend
whereas GHR-II and IGF-II did not change. Muscle IGF-I expression slightly
increased in groups L10 and L25 whereas GHR-I decreased in L10. GHR-II, IGF-II and
MyoG mRNA levels increased in L6 while MSTN did not differ between treatments. These
results suggest an apparent inhibition of hypertrophic mechanisms to counteract
excessive muscle growth hyperplasia in groups L10 and L25. In the adipose tissue,
a decrease of IGF-I mRNA levels was evident in group L10, whereas GHR-I did not
change. Similarly, IGF-II and GHR-II mRNA levels were not modified although a
slight and progressive increase was observed with the increase of the dietary
lipids. Taking these results together, it is clear a particularly fine tuning
of the GH/IGF system with 10% dietary lipid levels, suggesting that the energy
demands for growing pejerrey were met in this condition. Grants: PICT10-1493,
PIP0271.