INVESTIGADORES
CANOSA luis fabian
artículos
Título:
Regulation of the hypothalamic melanin-concentrating hormone neurons by sex steroids in the goldfish: possible role in the modulation of luteinizing hormone secretion
Autor/es:
CERDÁ-REVERTER JM; CANOSA LF; PETER RE
Revista:
NEUROENDOCRINOLOGY
Editorial:
KARGER
Referencias:
Año: 2006 vol. 84 p. 364 - 377
ISSN:
0028-3835
Resumen:
In teleost fish, melanin-concentrating hormone (MCH) is a cyclic heptadecapeptide releasedform pituitary during white background adaptation. In the periphery MCH concentrates melaningranules in melanophores thus lightening body color of fish. Evidences in mammalian specieshave demonstrated the involvement of MCH in the control of energy balance and reproductiveaxis. Information about hormonal regulation of MCH neurons in non mammalian system isscarce and nothing is known about its role in the regulation of reproductive axis. We here reportthe molecular characterization of two MCH precursors in the goldfish. Both precursors areperipherally expressed and the expression in the central nervous system is restricted to themediobasal hypothalamus. Hypothalamic MCH-mRNA production is upregulated during whitebackground adaptation. Both testosterone and estradiol stimulates MCH mRNA expression in the hypothalamus in a sex dependent manner. In addition in vitro experiments demonstrated thatgraded doses of salmon MCH stimulate LH secretion from pituitary dispersed cells but no GHsecretion. Results suggest that hypothalamic MCH might participate in the steroid positivefeedback loop on pituitary LH secretion