INVESTIGADORES
CABRERIZO franco Martin
artículos
Título:
A comprehensive analysis of direct and photosensitized attenuation of Toxoplasma gondii tachyzoites
Autor/es:
YAÑUK, JUAN G.; ALOMAR, M. LIS; GONZALEZ, M. MICAELA; ALONSO, ANDRÉS M.; ANGEL, SERGIO O.; COCERES, VERÓNICA M.; CABRERIZO, FRANCO M.
Revista:
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
Editorial:
ELSEVIER SCIENCE SA
Referencias:
Año: 2017 vol. 177 p. 8 - 17
ISSN:
1011-1344
Resumen:
In the present work, we have evaluated the effect of three different types of radiation: UVC (254 ± 5 nm), UVA (365 ± 20 nm) and visible (420 ± 20 nm) on different morphological and biological functions of Toxoplasma gondii tachyzoites. Briefly, UVC and UVA showed an inhibitory effect on parasite invasion in a dose-dependent manner. UVC showed the strongest effect inducing both structural damage (antigens) and functional inhibition (i.e., invasion and replication). On its own, visible light induces a quite distinctive and selective pattern of parasite-attenuation. This type of incident radiation inhibits the replication of the parasite affecting neither the capability of invasion/attachment nor the native structure of proteins (antigens) on parasites. Such effects are a consequence of photosensitized processes where phenol red might act as the active photosensitizer. The potential uses of the methodologies investigated herein are discussed.