INVESTIGADORES
ANGEL sergio Oscar
capítulos de libros
Título:
Apicomplexan and histone variants: What's new?
Autor/es:
VANAGAS L; CONTRERAS MS; ANGEL SO*
Libro:
Chromatin and epigenetics
Editorial:
IntechOpen
Referencias:
Año: 2019; p. 1 - 40
Resumen:
Plasmodiumspp and Toxoplasma gondii present a conservednucleosome composition based on canonical H3 and variants, H4, canonical H2Aand variants, and H2B. One-off, the phylum has also a variant H2B, named H2B.Z,which was shown to form a double variant nucleosome H2A.Z/H2B.Z. These histonesalso present conserved and unique post-translational modifications (PTMs).Histone variants have shown particular genomic localization and PTMs alongeuchromatin and heterochromatin, including telomere associated sequences (TAS),suggesting fine-grained chromatin structure modulation. Several othernon-histone proteins present remarkable participation in controlling chromatinstate, especially at TAS. Based on that, we discuss the role of epigenetics(PTMs and histone variants) in Plasmodiumand Toxoplasma gene expression,replication and DNA repair. We also discuss TAS structures and chromatincomposition and its impact on antigenic variant expression in Plasmodium.