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artículos
Título:
EVALUATION OF THE HAEMOCOMPATIBILITY OF TiO2 COATINGS OBTAINED BY ANODIC OXIDATION OF Ti-6Al-4V
Autor/es:
MARÍA LAURA VERA; JONATHAN SCHUSTER; MARIO R. ROSENBERGER; HAYDEE BERNARD; CARLOS E. SCHVEZOV; ALICIA E. ARES
Revista:
PROCEDIA MATERIALS SCIENCE
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 8 p. 366 - 374
ISSN:
2211-8128
Resumen:
The blood compatibility (haemocompatibility) is a requirement in materials used in prosthetic heart valves. No standardized methods are available to measure haemocompatibility in solid materials. However, a material could be considered haemocompatible if its surface does not modify the normal activation of the coagulation pathway and produces no damage in the blood components. In this work, the haemocompatibility of coatings obtained by anodic oxidation of Ti-6Al-4V (with H2SO4 1M and 40 to 70 V) with and without heat treatment (1h for 500ºC), is evaluated and compared with the haemocompatibility of the Ti-6Al-4V substrate and pyrolytic carbon. Standard clinical trials for clothing: Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) were adapted to evaluate the haemocompatibility of solid materials. Besides, the interactionbetween blood platelets and solid material were performed through an analysis of interfacial tensio n (γi,j), this parameter couldindicate the degree of preferential adsorption of each protein of the blood plasma. The ratio between albumin-material and fibrinogen-material interfacial tension, (γs,Alb/ γs,Fib), is an important parameter used to predict the platelets adhesion and the trendat the formation of cloth. The results of the clothing trials indicate that the tested surfaces would be haemocompatibles due to the values of PT and APTT obtained which were in range of the normal ones. In addition, the measured values of γs,Alb/ γs,Fib indicate that all the tested surfaces are more haemocompatible than pyrolitic carbon. The recrystalized films by heat treatment whichproduce some rutile crystals are the most haemocompatibles.