INVESTIGADORES
ALARCON laureano Martin
artículos
Título:
Interaction of hydroxy-xanthones with phosphatidylcholines: The effector decreases compressibility and increases the fluidity of membranes
Autor/es:
MORINI, M.A.; PEDRONI, V.I.; ALARCÓN, L.M.; VERDE, A.R.; MENDIOROZ, P.; APPIGNANESI, G.A.; SIERRA, M.B.
Revista:
CHEMISTRY AND PHYSICS OF LIPIDS
Editorial:
ELSEVIER IRELAND LTD
Referencias:
Año: 2020 vol. 231
ISSN:
0009-3084
Resumen:
This work reports the effect of hydroxy-xanthones (XAs) on 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) bilayers as determined by ultrasound velocimetry, densimetry and molecular dynamics simulations. XAs with different number of hydroxyl group were studied. Experimental results, in good agreement with molecular dynamics simulations, revealed that the presence of XAs in the systems studied increases fluidity while simultaneously decreses the compressibility of both membranes. This ´apparent contradiction´ ceases to exist when the particular geometrical structure of the xanthones is taken into account: the planar shape of their fused aromatic rings might allow them to pack efficiently among the hydrocarbon tails of the lipids, thus decreasing compressibility, while their presence weakens or disrupts methylene-methylene interchain interactions, thus increasing membrane fluidity and decreasing their melting temperature.