INVESTIGADORES
ALARCON laureano Martin
artículos
Título:
Experimental and computational studies of the effects of free DHA on a model phosphatidylcholine membrane
Autor/es:
A. VERDE; M. B. SIERRA; L. M. ALARCON; V.I. PEDRONI; G.A. APPIGNANESI; M.A. MORINI
Revista:
CHEMISTRY AND PHYSICS OF LIPIDS
Editorial:
ELSEVIER IRELAND LTD
Referencias:
Lugar: Amsterdam; Año: 2018 vol. 217 p. 12 - 18
ISSN:
0009-3084
Resumen:
Docosahexaenoic acid (DHA, 22:6) is a natural active compound that has raised considerable interest due to its several biological effects. In this work, effects of free DHA on the physicochemical properties of dipalmitoylphosphatidylcholine (DPPC) liposomes are investigated in terms of lipid membrane structure, by means of temperature-dependent zeta potential measurements, density studies and molecular dynamics simulations. Experimental results predict, in good agreement with simulations that DHA readily incorporates into DPPC liposomes, localizing at the lipid headgroup region. These data show that DHA induces changes in the lipid bilayer structure as well as in membrane fluidity.