GARCIA adolfo Martin
congresos y reuniones científicas
Multidimensional signatures of negatory inhibition are differentially disrupted in frontotemporal dementia and Parkinson?s disease
DÍAZ-RIVERA, MARIANO; BIRBA, AGUSTINA; FITTIPALDI, SOL; GONZALEZ-CAMPO, CECILIA; IBÁÑEZ, AGUSTÍN; GARCÍA, ADOLFO M.
Encuentro; XXXV Encuentro Anual de la Sociedad Argentina de Investigación en Neurociencias; 2020
Processing of linguistic negation distinctively recruits inhibitory mechanisms. Here, we assessed whether such domain can reveal neurocognitive markers of inhibitory disorders. We tested two groups with distinct neurodegenerative patterns along inhibitory circuits (behavioral variant frontotemporal dementia [bvFTD] and Parkinson?s disease [PD]), healthy controls (HCs), and patients with preserved inhibitory circuitry (Alzheimer?s disease [AD]). Subjects read negative and affirmative sentences and either performed or suppressed a manual response to them. We examined (a) measures of online oscillatory dynamics (via high-density EEG) as well as associations between such signatures and (b) neuroanatomical patterns (via voxel-based morphometry) and (c) fMRI-derived resting-state functional connectivity (FC). Relative to HCs, both bvFTD and PD patients exhibited altered oscillatory correlates of negatory inhibition ?viz., disruptions of inhibitory delta modulations for negation only in suppressed-response trials. Such abnormalities correlated with the volume and FC of inhibitory regions in both bvFTD (e.g., superior and orbitofrontal gyri) and PD (e.g., medial and precentral gyri and cerebellum). Conversely, AD patients showed no specific oscillatory patterns across conditions nor correlations with inhibitory regions. Briefly, linguistic negation can tap into the (dys)function of inhibitory mechanisms, paving the way for a potential neurocognitive marker of bvFTD and PD.