INVESTIGADORES
GARCIA adolfo Martin
capítulos de libros
Título:
Disruptions of frontostriatal language functions in Parkinsons disease
Autor/es:
GARCÍA, ADOLFO M.; BOCANEGRA, YAMILE; BIRBA, AGUSTINA; OROZCO, JUAN RAFAEL; SEDEÑO, LUCAS; IBÁÑEZ, AGUSTÍN
Libro:
The Neuroscience of Parkinsons Disease
Editorial:
Academic Press (Elsevier)
Referencias:
Lugar: Londres; Año: 2020; p. 413 - 430
Resumen:
Atrophy of frontostriatal pathways in Parkinson?s disease compromises diverselinguistic functions. To establish which of these disorders constitute candidate cognitive biomarkers of the disease, we review studies assessing phonetic/phonological, morphological, lexico-semantic, syntactic, and discourse-level dimensions in early stage patients. While morphological difficulties are inconsistent and discourse-level alterations seem nosologically unspecific, systematic disturbances emerge in particular phonetic (plosive articulation), lexico-semantic (action-verb processing), and syntactic (complex-sentence parsing) functions. Some such deficits are selective (not generalizedacross their overarching domain), partially specific (absent in non-motor disorders), primary (not secondary to overall cognitive dysfunction), associated to critical neurobiological abnormalities, and traceable in prodromal stages. Notably, new approaches for analyzing those dimensions allow identifying individual patients with over 90% accuracy. Although several challenges remain unaddressed and more programmatic research is needed, the incorporation of these tools in clinical settings could enhance screening protocols, differential diagnosis, disease-progression monitoring, and discrimination of patient profiles within the parkinsonian population.