INVESTIGADORES
BLANK viviana Claudia
congresos y reuniones científicas
Título:
An antitumor triazolyl peptidyl penicillin derivative inhibits Wnt/β-catenin pathway and angiogenesis
Autor/es:
ELIZABETH BARRIONUEVO; PATRICIA G. CORNIER; CARINA M. DELPICCOLO; DORA B. BOGGIAN; ERNESTO G. MATA; LEONOR P. ROGUIN; VIVIANA C. BLANK
Reunión:
Congreso; Reunión anual SAIC SAI SAFIS; 2018
Resumen:
In a previous work, we demonstrated that TAP7f, an antitumor penicillin derivative formed by penicillin linked to the dipeptide Leu-Phe through a triazole group, exhibited antimetastatic properties through the inhibition of cell adhesion, migration and invasion of highly metastatic melanoma B16F10 cells. This penicillin derivative also inhibited MMP-2 and 9 expression and activity. In order to extend the research on TAP7f antimetastatic properties, we investigated the effect of this derivative on Wnt/β-catenin pathway. By Western blot analysis, we found that a 10 µM concentration of TAP7f inhibited 51±11% (p