MECHANISMS UNDERLYING THE ANTI-TUMORAL EFFECTS OF THE FLAVONOID 2’-NITROFLAVONE IN HUMAN TRIPLE-NEGATIVE BREAST CANCER CELLS

VACHETTA VS; BLANK VC; BUSTOS M; MARDER MARIEL; ORTEGA MG; PAULINO ZUNINI M; ELOLA MT; TRONCOSO MF

Mar del Plata

Congreso; Reunión Anual de Sociedades de Biociencias; 2022

Sociedad Argentina de Investigacion clínica

Triple-negative breast cancer (TNBC) is one the most aggressive subtypes of mammarytumors. Flavonoids are polyphenolic compounds that cause several antineoplastic effects.We previously described that the synthetic flavonoid 2’-nitroflavone (2’NF) inhibits viability,survival and migration of human TNBC cells. Herein, our aim pointed to find outmechanisms that mediate 2’NF anti-tumoral effects in these cells. We first evaluated MDA-MB-231 cell cycle progression (propidium iodide staining, flow cytometry) upon treatment.2’NF (5 M, 72 h) decreased the percentage of cells in G1 phase from 59.30±1.63(control) to 43.00±.2.29% (p