Electromagnetic SAR Determination for Fe3O4 Nanoflowers Loaded in Melanoma Tumor and Comparison with Disipation in Agarose Ferrogel

ACTIS DG; BRUVERA IJ; SOTO, P.A.; ROGUIN LEONOR P; BLANK, VIVIANA C; FERNÁNDEZ VAN RAAP, M.B.; MENDOZA CELIS, P

Conferencia; 2021 AROUND-THE-CLOCK-AROUND-THE GLOBE -MAGNETICS CONFERENCE; 2021

Radiofrequency magnetic cycles of ex vivo melanoma tumor tissue loaded with Fe3O4 nanoflowers(NF) were measured for several field conditions and compared with the cycles of a ferrogel (FG)obtained incorporating the NF in agarose gel. Such cycles were obtained via an ac electromagnetictechnique[1]?[3]. Results were studied in order to understand usually reported SAR values differences between the actual application environment (tumor) and a typical characterization model (FG)for magnetic hyperthermia[4]?[6]. The linearity of the response, coercive field and SAR values wereanalyzed. Additionally, a novel method for the determination of the NF mean relaxation time fromthe cycles is presented. Results show a systematic difference in magnetic response at therapeuticfield setting (98 kHz, 17.4 kA/m) between the NF incorporated in tumors and those in the FG.