BLANK viviana Claudia
A solid- and solution-phase-based library of 2-methyl substituted penicillin derivatives and their effects on growth inhibition of tumor cell lines
BOGGIAN, DORA B; CORNIER, PATRICIA G; MATA, ERNESTO G; BLANK VIVIANA; CÁRDENAS MARIANO G; ROGUIN LEONOR P
Medicinal Chemistry Communications
Royal Society of Chemistry
Año: 2015 vol. 6 p. 619 - 625
We described the design, synthesis and antiproliferative properties of a series of twenty 2beta-methyl substituted penicillin derivatives. This analysis includes evaluation against HeLa and MCF-7 human tumor cell lines and LM3 and B16-F0 murine tumor cell lines. The epithelial cell line derived from the normal mammary gland of mice (NMuMG) and the mouse embryo fibroblast cell line (3T3) were used as controls (non-cancer cells).