Antiproliferative activity of various flavonoids and related compounds. Additive effect of interferon-alpha2b

BLANK VIVIANA; POLI CECILIA; MARDER MARIEL; ROGUIN LEONOR

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2004 vol. 14 p. 133 - 136

0960-894X

The antiproliferative activity of several natural and synthetic flavonoids and some related compounds was evaluated in vitro against a cell line derived from a human cervical carcinoma (WISH cells). According to their activities, the most potent derivatives were 20 -nitroflavone (14), 20 ,6-dinitroflavone (15) and the n-buthyl ester of caffeic acid (29). When these compounds were tested in the presence of recombinant human interferon-a2b (rhIFN-a2b), a cytokine exhibiting an antimitogenic action on WISH cells, an additive effect on cell growth inhibition was observed. Time course studies of the antiproliferative action exerted by the active derivatives or the rhIFN-a2b suggested that these compounds induced cell death.