Natriuretic Peptide Receptor Type A (NPRA)

NATALIA L RUKAVINA MIKUSIC; ROSON MI; KOUYOUMDZIAN, N.M.; CANTÚ SILVANA; BELISARIO E. FERNÁNDEZ; CHOI, M.R.

Encyclopedia of Signaling Molecules:

Springer Science+Business Media LLC

Año: 2017;

ANP, BNP, and URO bind to NPRA, a transmem-361 brane receptor encoded in Npr1 gene. NPRA acti-362 vation leads to a second messenger cascade363 signaling commanded by cGMP which triggers364 activation of other enzymes such as GKI. Its365 mRNA is expressed, among others, in the heart,366 kidney, vascular smooth muscle, skeletal muscle,367 endothelial, adipose, and brain tissues, as well as368 in the adrenal, lung, and testis. NPRA plays crit-369 ical physiological and pathophysiological roles on370 several target cells and tissue system mechanisms,371 such as cell growth, apoptosis, proliferation, and372 inflammation. It is related to different processes373 like cancer, hypertension, cardiac remodeling and374 hypertrophy, atherosclerosis, renal abnormalities,375 neuroprotection, fat tissue and skeletal muscle376 metabolism, insulin secretion, and377 hepatoprotection. Although new knowledgehave been updated in the last years, future studies 378with molecular biology techniques will provide 379complementary insights about how genetic alter- 380ations of NP receptors could be associated to the 381origin and development of human pathologies. 3