GIRONACCI Mariela Mercedes
congresos y reuniones científicas
CENTRALLY ANGIOTENSIN-(1-7) DECREASES WITH AGE
GIRONACCI MARIELA M; SIRRI MF; CARRETERO OA; CERNIELLO FM
Congreso; 27TH SCIENTIFIC MEETING OF THE INTERNATIONAL SOCIETY OF HYPERTENSION; 2018
Objectives: The depressor axis of the renin-angiotensin system (RAS) exertscerebroprotective effects. We hypothetized that a centrally dysbalance existsbetween both axis that may contribute to hypertension development and cognitivedysfunction with age. Our aim was to determine Ang-(1-7) and Ang II levelsin different areas of the brain in normotensive and spontaneously hypertensive(SHR) rats of different agesMethods: Hypothalamus (HT), brain stem (BS), hippocampus (HC) and braincortex (C) from 1, 3 and 12-months-old rats were isolated. Ang levels werequantifi ed by radioimmunoassayResults: Ang-(1-7) levels decreased with age in HT, BS and C from normotensiverats. Regarding SHR, an increase in Ang-(1-7) levels with age was observed inBS, HC and HT when 1 and 3 months-old rats were compared but not signifi cantdifferences were observed between 3 and 12 months-old rats, except in brainstemwhere Ang-(1-7) decreased. Ang-(1-7) levels in C did not signifi cantly changewith age in SHR. In all the studied areas Ang-(1-7) levels in 1-month-old ratswere greater in normotensive than in SHR. Ang II levels increased with age in all the studied areas both in normotensive and SHR. However, AngII levels in HT,BS and C of 12-months-old rats decreased in comparison to 3-months-old rats.1-month-old SHR showed greater Ang II levels in BS and C in comparison tonormotensive young rats. On the contrary, Ang II levels in HT of young SHR werelower than in normotensiveConclusion: Our results show that brain Ang-(1-7) levels in normotensiverats decreased while Ang II levels increased with age. The fact that Ang-(1-7)increased with age in hypertension may be due to a compensatory mechanism.