Neuro-Immune Crosstalk in Hypertension Pathophysiology

CALVILLO L; GIRONACCI MM; CROTTI L; MERONI P; PARATI G

NATURE REVIEWS CARDIOLOGY

NATURE PUBLISHING GROUP

Lugar: Londres; Año: 2019

1759-5002

Hypertension is an important risk factor for cardiovascular morbidity and mortality and for events such as myocardial infarction, stroke, heart failure, and chronic kidney disease, representing a major determinant of disability adjusted life years. Despite its importance, the pathogenesis of essential hypertension is still poorly understood, with several mechanisms being involved in a complex manner. A dialogue between bone marrow, microglia and immune mediators is suggested as a possible ?network? underlying the development of arterial hypertension, in particular by a mechanism involving nervous system, bone marrow, cytokines and peptides such as Neuropeptide Y, Substance P, Angiotensin II and Angiotensin (1-7). Chronic psychological stress also seems to have a role in increasing the risk of hypertension, likely through the activation of neuro-immune pathways. In the present review we summarize the data available on the possible role of the neuro-immune crosstalk in the origin and maintenance of arterial hypertension, with implications for recovery and rehabilitation after cardiac and cerebral injuries.