Contribution of angiotensin-(1-7) to the pathophysiology of hipertension

MARIELA M GIRONACCI

Brazilian Journal of Hypertension

Año: 2005 vol. 12 p. 147 - 152

1519-7522

Among the functionally bioactive peptides of the renin angiotensin system, angiotensin-(1-7) is considered the most pleiotropic because it exerts effects that may be similar to, different or opposite from those displayed by Ang II. Ang-(1-7) lacks the pressor, dipsogenic orstimulatory effect on aldosterone release characteristic of Ang II. In contrast, it produces vasodilation, natriuresis and diuresis and inhibits angiogenesis, cell growth and barorefl ex control of blood pressure. Taken together, these fi ndings suggest that Ang-(1-7) is an endogenous counterregulator of the pressor and trophic actions of Ang II, playing an important role in the regulation of cardiovascular and renal function and the pathophysiology of hypertension.