INVESTIGADORES
ROMEO Hernan Esteban
artículos
Título:
Functionalized bridged silsesquioxane-based nanostructured microspheres: ultrasound-assisted synthesis and in vitro cytotoxicity characterization
Autor/es:
HERNÁN E. ROMEO; MÓNICA CAMEO; MARÍA V. CHOREN; MARÍA A. FANOVICH
Revista:
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
Editorial:
SPRINGER
Referencias:
Lugar: Berlin; Año: 2011 vol. 22 p. 935 - 943
ISSN:
0957-4530
Resumen:
Different kinds of polymers have been employed in medicine as biomaterials for different purposes. In recent years, considerable attention has been focused on the development of new drug-delivery systems in order to increase bio-availability, sustain, localize and target drug action in the human body. The versatility of the sol-gel processing to synthesize nanostructured materials and the possibility of incorporating organic molecules into the matrix of the final hybrid material, represent a novel and attractive path to the synthesis of new functionalized hybrid biomaterials with advanced properties. In this work, acetylsalicylic acid (ASA)-functionalized hybrid microspheres based on bridged silsesquioxanes synthesized via ultrasound-assisted sol-gel processing, were characterized. An investigation concerning the cytotoxic response of these new microspheres on CHO-K1 cells was accomplished based on ISO 10993-5 standard (Biological Evaluation of Medical Devices). Microspheres incorporating ASA showed a cytotoxic effect when pure extracts of the microspheres were analyzed, however, they strongly diminished their cytotocicity as the extracts were diluted. When a 10%-concentration extract was employed, hybrid microspheres were shown to be non cytotoxic. These results are promising for considering these novel functionalized organic-inorganic microspheres as potential drug-carriers to be employed in drug delivery-related applications.