Antimicrobial nanocomposite membranes for dental tissue engineering

FURTOS, GABRIEL; RIVERO GUADALUPE; RAPUNTEAN SORIN; ABRAHAM, GUSTAVO A.

Simposio; XVI Simposio Latinoamericano de Polímeros; 2018

In guided tissue/bone regeneration (GTR/GBR), a barrier membrane is used to prevent fibroblastic cells from colonizing an intraosseous wound during healing, allowing slowly migrating bone cells to fill the defect, resulting in direct bone regeneration. Compared with poly(lactic acid) (PLA) the degradation of poly(-caprolactone) (PCL) does not produce a local acidic environment and degrades more slowly. Nanohydroxyapatite (nHAp) has good biocompatibility, bioactivity, high osteoconductivity and osteoinductivity properties [1]. An antimicrobial property of GBR is very important to control and/or reduce bacterial contamination of the periodontal defect to enhance periodontal regeneration. In this work, different electrospun antibiotic-loaded PCL/nHAp nanocomposites were obtained by varying antibiotic/nHAp ratio.