Electrospinning of amoxicillin-loaded biodegradable polycaprolactone/nano hydroxyapatite nanofibers

FURTOS, GABRIEL; RIVERO, GUADALUPE; ABRAHAM, GUSTAVO A.

Conferencia; MC Meeting and Workshop on "Composite, nanofabrication, food and pharma related application and packaging, controlled release; 2015

In guided bone regeneration (GBR), a barrier membrane is used to prevent fibroblastic cells from colonizing an intraosseous wound during healing, allowing slowly migrating bone cells to fill the defect, resulting in direct bone regeneration. Compared with poly(lactic acid) (PLA), poly(-caprolactone) (PCL) degradation does not produce a local acidic environment and degrades very slowly. Nanohydroxyapatite (nHAp) shows good biocompatibility, bioactivity, high osteoconductive, and/or osteoinductive properties. Antimicrobial properties of GBR is very important to control and/or reduce bacterial contamination of the periodontal defect to enhance periodontal regeneration. In this work, porous matrices composed of PCL and nHAp loaded with amoxicillin (AMX) were prepared as material designed for biomedical applications. Different electrospun antibiotic-loaded nanocomposites were obtained by varying AMOX/nHAp ratio, to produce a series of PCL/AMOX, PCL/nHAp and PCL/AMOX/nHAp matrices. The structural, morphological, surface and thermal properties were characterized by using X-ray diffraction (XRD), scanning electron microscopy (SEM, EDAX), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and contact angle measurements. The results reveal that these electrospun nanocomposite amoxicillin-loaded scaffolds could be a promising biodegradable material for biomedical application. Antimicrobial testing is under progress.