Amoxicillin-loaded electrospun nanocomposite membranes for dental applications

RIVERO GUADALUPE; FURTOS, GABRIEL; RAPUNTEAN SORIN; ABRAHAM, GUSTAVO A.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

WILEY-LISS, DIV JOHN WILEY & SONS INC

Lugar: New York; Año: 2016 vol. 105 p. 966 - 976

1552-4973

Electrospun nanocomposite matrices based on poly(ε-caprolactone) (PCL), anohydroxyapatite (nHAp) and amoxicillin (AMX) were designed and investigated fordental applications. nHAp provides good biocompatibility, bioactivity, osteoconductivity and osteoinductivity properties, and AMX, as antibiotic model,controls and/or reduces bacterial contamination of periodontal defects while enhancing tissue regeneration. A series of polymeric nanocomposites was obtained by varying both the antibiotic and nHAp contents. Fibrous membranes of different compositions were obtained by electrospinning technique, and morphological, thermal, mechanical and surface properties were characterized. The incorporation of AMX seemed to alter the nHAp distribution within the microfibrous matrix. The interaction between AMX and nHAp affected the mechanical performance and modulated the antibiotic release behavior. AMX release profiles presented a burst release that depended on nHAp content, followed by a slow release stage where the drug content (85-100%) was released in 3 weeks. The antimicrobial activity of the AMX-loaded membranes was tested with four bacterial strains depended on both the drug and nHAp contents. Extensive mineralization in simulated body fluid (SBF) was evidenced by SEM/EDX analysis after 21 days. The studied electrospun nanocomposite amoxicillin-loaded membranes could be a promising fibrous-based antibiotic carrier system for dental and tissue engineering applications.Nota: G. Rivero y G. Furtos contribuyeron igualmente y son ambos 1er autor de la publicación.