Antiviral effect of a synthetic brassinosteroid on the replication of vesicular stomatitis virus in Vero cells

CARINA ROMANUTTI; VIVIANA CASTILLA; CELIA E. COTO; MÓNICA B. WACHSMAN

International journal of antimicrobial chemotherapy

Elsevier

Año: 2007 vol. 29 p. 311 - 316

0305-7453

The antiviral mode of action of the synthetic brassinosteroid (22S,23S)-3b-bromo-5a,22,23-trihydroxystigmastan-6-one (6b) against vesicular stomatitis virus replication in Vero cells was investigated. Time-related experiments showed that 6b mainly affects a late event of virus growth cycle. Virus adsorption, internalization or early RNA synthesis are not the target of the inhibitory action. Results obtained indicate that the antiviral compound adversely affects virus protein synthesis and viral mature particle formation.