Placento-cardiopatía fetal y angiogénesis en un modelo murino de ingesta materna de alcohol

GISELA S. GUALDONI; ELISA CEBRAL; MARTÍN R. VENTUREIRA

Cali

Simposio; III Simposio Colombiano de placenta e interacción materno-fetal; 2020

Universidad del Valle

Adequate placental development leads normal fetal growth and the future adult health1.Intrauterine growth restriction, cardiopathy, neuropathy and fetal programming diseasesrelated to maternal alcohol consumption2could be associated with altered placentation3.Our objective was study if perigestational alcohol consumption up to organogenesisproduces placental anomaly, through vascular endothelial growth factor (VEGF)deregulation and oxidative stress. Ethanol 10%/ drinking water was administered tomouse females for 15 days before and up to day 10 of gestation, and pregnancy continuedwith water until gestational day 13 (TF). Control females consumed ethanol-free water(CF). The 27% of TF-feto-placental units had labyrinthine histological abnormalities(disorganized vascularization) and fetal malformations (p