IBBEA   24401
INSTITUTO DE BIODIVERSIDAD Y BIOLOGIA EXPERIMENTAL Y APLICADA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Social distancing and strengthened research community efforts to fight pandemics: producing a low-cost SARS-CoV-2 antigen
Autor/es:
CONSORCIO ARGENTINO ANTICOVID; ZELADA ET AL
Reunión:
Congreso; Congreso de Sociedad Argentina de Investigaciones Bioquímicas (SAIB) - Sociedad Argentina de Microbiología General (SAMIGE); 2020
Institución organizadora:
Sociedad Argentina de Investigaciones Bioquímicas (SAIB) - Sociedad Argentina de Microbiología General (SAMIGE)
Resumen:
At the beginning of the worldwide known SARS-CoV-2 pandemic, we have designed a strong collaborative working flowamong researchers of different institutes in Argentina, taking advantage of each member´s expertise. This effective workingnetwork allowed us to accelerate research and developments in a synergistic way. Our goals were to obtain antigens (proteinsand multiprotein complexes) useful for the diagnosis and therapy against COVID19 and to make these developments availableto society in the fastest and most cost-accessible possible fashion. In this scenario, we will present the advances regarding thescalable production of the receptor-binding domain (RBD) of the Spike protein of SARS-CoV-2. Also, we will present theimprovements in the design of an antigen with better immunogenic characteristics compared with those of wild-typemonomeric RBD, obtained through the covalent coupling of RBD with other proteins. Our efforts opened a big window ofnew and promising collaborative arms with other groups outside of our consortium: the purified proteins were useful for antiSARS-CoV-2 antibody detection, IgY production, camelid immunization for nanobody selection, vaccine investigations, andmonoclonal antibody developments. We are confident not only that we will be able to positively contribute to the pandemicsolution?s opportunities, but that the collaborative way among institutions ?often underexploited? we chose to achieve to helpfight pandemics will remain after the emergency is gone