IBBEA   24401
INSTITUTO DE BIODIVERSIDAD Y BIOLOGIA EXPERIMENTAL Y APLICADA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
ATP detection and its role as phagostimulant in blood feeders
Autor/es:
CANO, A; BARROZO, RB; ORTEGA INSAURRALDE, I; INSAUSTI, T; SALAS MORALES, H; DEGENNARO, M
Lugar:
Hangzhou
Reunión:
Congreso; 10th Conference of Asia-Pacific Association of Chemical Ecologists; 2019
Institución organizadora:
APACE
Resumen:
Oncea blood-sucking insect reaches the host skin, it bites and tastes the blood.Gustatory evaluation of chemicals of the blood occurs in contact chemoreceptorssituated in the pharynx. Most blood-sucking insects are highly sensitive to adenosinetriphosphate (ATP), triggering gorging responses. Here, we characterized the ATPreceptor through pharmacological experiments and traced the pharyngealchemoreceptors to the brain to uncover central regions where gustatoryinformation is processed in the kissing bug R.prolixus. The ingested volume and pumping parameters of the pharyngeal muscleswere significantly reduced or enhanced when insects were fed with knownmammals? purinoceptor antagonists or agonists, respectively. We traced the pharynxneurons by means of anterograde backfills to the brain. Stained pharyngeal neuronaltracks innervated the tritocerebrum through the labral nerves. Untangling theATP detection mechanism will provide with novel targets in the search of tools addressedto diminish interactions between disease-vector insects and humans.