Development and histo-functional cardiac abnormalities in murine fetuses after perigestational alcohol consumption up to early organogenesis

C. SOBARZO; CEBRAL ELISA; VENTUREIRA MARTIN; C. BARBEITO; CHALIMONIUK GABRIELA

CABA

Congreso; Reunión conjunta de Sociedades de Biociencias; 2017

SAIC

Maternal alcohol consumption leads to congenital diseases and organ malformation, in which the developing heart is one of main target for teratogenic maternal alcohol effects. The aim of this study was to assess if perigestational alcohol intake up to day 10 of gestation (D10) alters the heart rate and ventricular and atrial myocardial and endocardial arrangement, and modifies the proliferation and apoptotic indexes, in fetal heart at day 13 of gestation (D13). Ethanol 10% in drinking water was administered to murine CF-1 females for 15 days before and up to D10, and gestation continued with water until D13 (treated females (TF)). Control females (CF) were administered with drinking water without ethanol. Both in morphologically abnormal and normal fetuses of TF, the hearts presented thinner trabeculation and discontinuous endocardium (Hematoxylin-eosin), and the ventricular and atrial myocardial wall thickness were reduced (p