IBBEA   24401
INSTITUTO DE BIODIVERSIDAD Y BIOLOGIA EXPERIMENTAL Y APLICADA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
GAP 3D Structure is conserved through the vertebrate lineage
Autor/es:
PEREZ SIRKIN, DANIELA; KAMECH N; SOMOZA, GM; DUFOUR, S; VISSIO, PAULA G.
Lugar:
Chascomús
Reunión:
Jornada; XVI JORNADAS DE LA SOCIEDAD ARGENTINA DE BIOLOGIA; 2014
Institución organizadora:
Sociedad Argentina de Biología
Resumen:
GnRH associated peptide (GAP) is the C-terminal portion of the GnRH pre-prohormone. Although it was reported that GAP can be co-secreted with GnRH, this peptide is generally considered as a residual sequence. When we characterized the full GnRH transcripts of the teleost fish Cichlasoma dimerus, the putative aminoacid sequence of GAP presented high similarity with that of other teleosts. Consider these, the aim of this work was to evaluate if GAP sequences and tridimensional structures are conserved in vertebrates. GAP sequences were obtained from different databases and then a comparative analysis of the primary amino acid sequences, a phylogenetic analysis and a study of the predicted 3D structures were performed. The results show a high conservation in GAP 3D structure among vertebrates in type I and type II GnRH variants, but not in type III and IV. This conservation through the vertebrate lineage suggest that, in spite of what it is thought, GAP may have a conserved function.