IBBEA 24401
INSTITUTO DE BIODIVERSIDAD Y BIOLOGIA EXPERIMENTAL Y APLICADA
Unidad Ejecutora - UE
artículos
Título:
Effects of waterborne exposure to 17B estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus
Autor/es:
F. J. MEIJIDE; G. REY VÁZQUEZ; Y. G. PIAZZA; P. A. BABAY; R. F. ITRIA; F. L. LO NOSTRO
Revista:
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 124 p. 82 - 90
ISSN:
0147-6513
Resumen:
Estrogenicchemicalsareoftendetectedintheaquaticenvironmentandcannegativelyaffectanimaldevelopment andreproduction.Inteleost fishes, thehormonalregulationduringacriticalperiodoflarvaldevelopmenthasastronginfluence ongonadalsexdifferentiation;thusthisprocessmaybeaf-fected bytheexposuretoenvironmentalestrogens.Inthisstudy,we first assessedthelethalacutetoxicityofthenaturalestrogen17β-estradiol(E2) andtheweakerestrogenmimics4-tert-octylphenol(OP) and4-nonylphenol(NP)onlarvalstagesoftheSouthAmericancichlid fish Cichlasomadimerus. Inafurther experiment,weanalyzedtheeffectsofchronicwaterborneexposuretoE2 and OPongonaddevelopment andsexdifferentiation.ExposuretohighconcentrationsofE2 had apronouncedfeminizingeffect directingsexdifferentiationtowardsovariandevelopment,whiletestisdevelopmentwasinhibitedat alower,environmentallyrelevantconcentration.AmongOP-exposed fish, 15?38.5% ofthemalesex-hibited testicularoocytes(TOs),acommonlyreportedbiomarkerofestrogenicexposure.However,sinceTOs werealsorecordedincontrolmalesandtheproportionofmaleswithTOswasnotsignificantlyhigher inOPtreatments,theiroccurrencecouldnotbeattributedtoOPexposure.Inaddition,TOsdidnotseem toimpairmalegonaddevelopmentandfunctionalitysincenormalspermatogenesiswasobservedin testesofOP-treated fish. TheseresultsindicatethatE2 occurring intheSouthAmericanaquaticen-vironment mayaffectmalereproductivedevelopmentandposeariskforwild C. dimerus, especiallyunder prolongedexposure,whiletheeffectsofweakerxenoestrogenssuchasOPwouldbenegligibleforgonad developmentinthisspecies.Asillustratedbythisstudy,thenaturaloccurrenceofTOsindicatesthat conclusionsconcerningthecausesofthisphenomenonmustbedrawnwithcare.
